GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12143789 | 1 | rs56101873 | chr1:119474790 | WARS2 | chr1:119573841-119683295:- | 0.26 | 3.49 | 0.000532 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs2241437 | 1 | rs56104203 | chr2:86336256 | LOC90784 | chr2:86247339-86250991:- | -0.42 | -4.38 | 1.49E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs12188164 | 1 | rs56104584 | chr5:437542 | C5orf55 | chr5:441645-443258:- | 0.33 | 8.44 | 3.87E-16 | Cystic fibrosis severity |
| THCA | cis | rs4038131 | 1 | rs56105592 | chr2:17779641 | GEN1 | chr2:17935162-17966632:+ | 0.58 | 7.52 | 2.66E-13 | Psychosis and Alzheimer's disease |
| THCA | cis | rs11083475 | 1 | rs56113315 | chr19:39184166 | LGALS7 | chr19:39261608-39264157:- | -0.22 | -4.61 | 5.1E-6 | Heart rate |
| THCA | cis | rs3105593 | 1 | rs56118429 | chr15:50923849 | SPPL2A | chr15:50999739-51057910:- | 0.26 | 7.04 | 6.76E-12 | QT interval |
| THCA | cis | rs1061377 | 1 | rs56119980 | chr4:39141010 | KLHL5 | chr4:39046659-39123828:+ | -0.22 | -6.04 | 3.18E-9 | Uric acid levels |
| THCA | cis | rs9815354 | 1 | rs56121764 | chr3:41883975 | ULK4 | chr3:41288091-42003660:- | 1.04 | 19.01 | 1.99E-60 | Diastolic blood pressure |
| THCA | cis | rs59374417 | 1 | rs56124423 | chr3:119278163 | ADPRH | chr3:119298523-119308791:+ | -0.22 | -3.66 | 0.000283 | Vitiligo |
| THCA | cis | rs7647973 | 1 | rs56127630 | chr3:49438036 | GMPPB | chr3:49758932-49761384:- | 0.17 | 3.86 | 0.000127 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs56127630 | chr3:49438036 | P4HTM | chr3:49027341-49044579:+ | -0.17 | -4.27 | 2.4E-5 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs56127630 | chr3:49438036 | WDR6 | chr3:49044637-49053386:+ | 0.17 | 3.58 | 0.000384 | Menarche (age at onset) |
| THCA | cis | rs874628 | 1 | rs56128769 | chr19:18302261 | IL12RB1 | chr19:18170371-18209626:- | -0.09 | -3.35 | 0.000861 | Multiple sclerosis |
| THCA | cis | rs6012564 | 1 | rs56131635 | chr20:47774343 | ARFGEF2 | chr20:47538275-47653229:+ | -0.12 | -3.82 | 0.000154 | Anger |
| THCA | cis | rs6012564 | 1 | rs56131635 | chr20:47774343 | CSE1L | chr20:47662838-47713484:+ | 0.4 | 10.02 | 1.36E-21 | Anger |